5-Bromocytosine

5-Bromocytosine is a Cytosine (HY-I0626) derivative. 5-Bromocytosine can be incorporated into cellular DNA and promote DNA chain breakage and cross-linking under ultraviolet irradiation[1][2].

Product Specifications

CAS Number

[2240-25-7]

UNSPSC

12352200

Hazard Statement

H302, H315, H317, H318, H335

Target

DNA Alkylator/Crosslinker; Drug Derivative

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-amino-5-bromopyrimidin-2-1h-one.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C1N=C(C(Br)=CN1)N

Molecular Formula

C4H4BrN3O

Molecular Weight

190.00

Precautions

H302, H315, H317, H318, H335

References & Citations

[1]Aschi M, et al. A Combined Experimental and Computational Study of Halogen and Hydrogen Bonding in Molecular Salts of 5-Bromocytosine. Molecules. 2021 May 23;26 (11) :3111. |[2]Taguchi H, et al. Bromination of cytosine derivatives. The Journal of Organic Chemistry, 1979, 44 (24) : 4385-4393.