Propargyl-PEG4-CH2CO2-NHS
Propargyl-PEG4-CH2CO2-NHS (compound P-7) is a PEG derivative containing a propargyl group and an NHS group. Propargyl-PEG4-CH2CO2-NHS is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-CH2CO2-NHS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1].
Product Specifications
CAS Number
[2144777-76-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg4-ch2co2-nhs.html
Smiles
C#CCOCCOCCOCCOCC(ON1C(CCC1=O)=O)=O
Molecular Formula
C15H21NO8
Molecular Weight
343.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Woo Sung-ho, et al. Composé comprenant un groupe auto-immolable et conjugué ligand-médicament le comprenant. WO2024005460A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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