XY077
XY077 (compound 14a) is a RORγ inverse agonist with the IC50 of 0.004 μM. XY077 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ROR
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xy077.html
Smiles
O=C(NC1=CC2=C(C=C1)CCCN2S(=O)(CC3=CC=C(C(F)(F)F)C=C3)=O)CC4=CC=C(S(=O)(CC)=O)C=C4
Molecular Formula
C27H27F3N2O5S2
Molecular Weight
580.64
References & Citations
[1]Wu XS, et al. Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer. Acta Pharmacol Sin. Published online May 2, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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