I-As-1
I-As-1 is a potent inhibitor of Bruton’s tyrosine kinase (BTK), with the IC50 of 2.35 nM. I-As-1 shows antiproliferative activities among Ramos cells and OCI-LY10 cells with IC50s of 0.52 μM and 0.11 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/i-as-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C[As]1SCCS1)N2CCC[C@@H](N3C4=NC=NC(N)=C4C(C5=CC=C(C=C5)OC6=CC=CC=C6)=N3)C2
Molecular Formula
C26H27AsN6O2S2
Molecular Weight
594.58
References & Citations
[1]Yang Zhao, et al. Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. J Med Chem. 2024 Apr 11;67 (7) :5458-5472.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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