Pabinafusp alfa
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1].
Product Specifications
CAS Number
2140211-48-7
Product Name Alternative
JR-141
UNSPSC
12352203
Target
Transferrin Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pabinafusp-alfa.html
Purity
97.49
Solubility
10 mM in DMSO
Smiles
[Pabinafuspalfa]
Molecular Weight
(265.16 kDa)
References & Citations
[1]Morimoto H, et al. Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice. Mol Ther Methods Clin Dev. 2022 May 10;25:534-544.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Available Sizes
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