Pabinafusp alfa

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1].

Product Specifications

CAS Number

[2140211-48-7]

Product Name Alternative

JR-141

UNSPSC

12352203

Target

Transferrin Receptor

Type

Inhibitory Antibodies

Related Pathways

Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pabinafusp-alfa.html

Purity

97.49

Solubility

10 mM in DMSO

Smiles

[Pabinafuspalfa]

Molecular Weight

(265.16 kDa)

References & Citations

[1]Morimoto H, et al. Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice. Mol Ther Methods Clin Dev. 2022 May 10;25:534-544.