Neohesperidin dihydrochalcone

Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

Product Specifications

CAS Number

[20702-77-6]

Product Name Alternative

Neohesperidin DC; NHDC

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Neohesperidin_dihydrochalcone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1O[C@H]([C@H]([C@@H]([C@H](O2)CO)O)O)[C@@H]2OC3=CC(O)=C(C(O)=C3)C(CCC4=CC(O)=C(C=C4)OC)=O

Molecular Formula

C28H36O15

Molecular Weight

612.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi JM, et al. Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death. Biol Pharm Bull. 2007 Feb;30 (2) :324-30.|[2]Kashani-Amin E, et al. Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector. FEBS Lett. 2013 Mar 18;587 (6) :652-8.|[3]Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29 (2) :722-9.|[4]Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40 (1) :74-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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