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(R) -SKF 38393 (hydrochloride)

(R) -SKF 38393 ((±) -SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R) -SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].

Product Specifications

Product Name Alternative

(±) -SKF-38393 (hydrochloride) ; SKF-38393A (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Dopamine Receptor; Potassium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-skf-38393-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C=C2[C@H](CNCCC2=C1)C3=CC=CC=C3)O.Cl

Molecular Formula

C16H18ClNO2

Molecular Weight

291.77

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R- (+) -7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62 (1) :119-26.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12520B/R-SKF-38393-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12520B/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[81702-42-3]

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