DTAG-13-NEG

DTAG-13-NEG is a negative control of dTAG-13 (HY-114421) . dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest[1][2].

Product Specifications

CAS Number

[2451573-90-1]

UNSPSC

12352005

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dtag-13-neg.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(OCCCCCCNC(COC3=C(C=CC=C3)[C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=O)C=CC=C2C(N1C7C(N(C(CC7)=O)C)=O)=O

Molecular Formula

C58H70N4O15

Molecular Weight

1063.19

References & Citations

[1]Behnam Nabet, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.|[2]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.