UK4b
UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1].
Product Specifications
CAS Number
[2171000-87-4]
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/uk4b.html
Purity
96.17
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC(C=C(/C=C1C(NC(NC/1=O)=O)=O)C=C2)=C2OCCCCC3CCCCC3
Molecular Formula
C21H25ClN2O4
Molecular Weight
404.89
References & Citations
[1]Weaver L M, et al. A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model[J]. Scientific Reports, 2024, 14 (1) : 6959.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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