Q14

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM) . Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism[1].

Product Specifications

Product Name Alternative

Q14 peptide

UNSPSC

12352209

Target

Deubiquitinase; Mitophagy

Type

Peptides

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/q14.html

Smiles

O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N4[C@@H](CCC4)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CNC(C)=O

Molecular Formula

C101H168N32O23

Molecular Weight

2198.62

References & Citations

[1]Qin X, et al. Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30[J]. Autophagy, 2022, 18 (9) : 2178-2197.