What is the catalog number for Q14?

The catalog number for Q14 is HY-P10416.

What sizes are available for Q14?

Q14 is available in the following size(s): 1 Each.

Q14 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Q14?

Q14 is manufactured by QuantiMol.

What is the estimated delivery time for Q14?

Estimated delivery time for Q14 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Q14?

The safety data sheet for Q14 is available here: http://file.medchemexpress.com/batch_PDF/HY-P10416/.

Q14

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM) . Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism[1].

Product Specifications

Product Name Alternative

Q14 peptide

UNSPSC

12352209

Target

Deubiquitinase; Mitophagy

Type

Peptides

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/q14.html

Smiles

O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N4[C@@H](CCC4)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CNC(C)=O

Molecular Formula

C101H168N32O23

Molecular Weight

2198.62

References & Citations

[1]Qin X, et al. Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30[J]. Autophagy, 2022, 18 (9) : 2178-2197.