Co (III) protoporphyrin IX chloride

Co (III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co (III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co (III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models[1][2][3][4].

Product Specifications

CAS Number

[102601-60-5]

Product Name Alternative

Protoporphyrin IX cobaltic chloride; CoPPIX-Cl

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Bcl-2 Family; Caspase; Cytochrome P450; Heme Oxygenase (HO) ; Keap1-Nrf2

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/co-iii-protoporphyrin-ix-chloride.html

Purity

95.0

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC(O)=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Co+3]3([N-]78)([N-]54)[Cl-])O

Molecular Formula

C34H32ClCoN4O4

Molecular Weight

655.03

Precautions

H302, H315, H319, H335

References & Citations

[1]Shan Y, et al. Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. FASEB J. 2006 Dec;20 (14) :2651-3.|[2]Drummond GS, et al. The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci U S A. 1982 Apr;79 (7) :2384-8.|[3]Li J, et al. Cobalt-protoporphyrin enhances heme oxygenase 1 expression and attenuates liver ischemia/reperfusion injury by inhibiting apoptosis. Mol Med Rep. 2018 Mar;17 (3) :4567-4572.|[4]Willix JL, et al. Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis. Antimicrob Agents Chemother. 2020 Mar 24;64 (4) :e01819-19.