Cynomolgus / Rhesus macaque OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag
Cynomolgus / Rhesus macaque OX40 Ligand, Mouse IgG2a Fc Tag (OXL-R5259) is expressed from human 293 cells (HEK293) . It contains AA Gln 51 - Leu 183 (Accession # F7FL80-1) . In the region Gln 51 - Leu 183, the AA sequence of Cynomolgus and Rhesus macaque OX40 Ligand are homologus.
Product Specifications
Background
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
Specifications
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 42.5 kDa. The protein migrates as 47-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
F7FL80-1
Expression Region
Gln 51 - Leu 183
Host
HEK293
Target
OX40 Ligand
Conjugation
Unconjugated
Tag
N-mFc (mIgG2a)
Source
Cynomolgus / Rhesus macaque
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.1 EU per μg
Purity
90%
Bioactivity
Immobilized Cynomolgus / Rhesus macaque OX40, His Tag (Cat. No. OX0-C5220) at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque OX40 Ligand, Mouse IgG2a Fc Tag (Cat. No. OXL-R5259) with a linear range of 0.1-3 ng/mL (QC tested).
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Additives
Trehalose
Molecular Weight
42.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/OXL-R5259.pdf
Species
Cynomolgus / Rhesus macaque
Curated Selection
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