[D-Trp11]-Neurotensin

[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].

Product Specifications

CAS Number

[73634-68-1]

UNSPSC

12352209

Target

Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-trp11-neurotensin.html

Solubility

H2O

Smiles

O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H]3CCC(N3)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC5=CNC6=CC=CC=C56

Molecular Formula

C80H122N22O19

Molecular Weight

1695.96

References & Citations

[1]Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61 (3) :309-12.|[2]Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1 (4) : 253-9.