[D-Trp11]-Neurotensin
Product Specifications
UNSPSC Description
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].
Target Antigen
Neurotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/d-trp11-neurotensin.html
Solubility
H2O
Smiles
O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H]3CCC(N3)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC5=CNC6=CC=CC=C56
Molecular Weight
1695.96
References & Citations
[1]Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12.|[2]Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3057/D-Trp11-Neurotensin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3057/
Clinical Information
No Development Reported
CAS Number
73634-68-1
Curated Selection
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