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(S, S, S) -AHPC-Boc

(S, S, S) -AHPC-Boc is the isomer of (S, R, S) -AHPC-Boc (HY-123109), and can be used as an experimental control. (S, R, S) -AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S, R, S) -AHPC-Boc is used in PROTAC technology[1].

Product Specifications

CAS Number

[1797406-74-6]

Product Name Alternative

(S, S, S) -VH032-Boc

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-s-s-ahpc-boc.html

Purity

97.21

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1C[C@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)[C@H](C(C)(C)C)NC(OC(C)(C)C)=O

Molecular Formula

C27H38N4O5S

Molecular Weight

530.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10 (8) :1770‐1777.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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