(S, S, S) -AHPC-Boc
(S, S, S) -AHPC-Boc is the isomer of (S, R, S) -AHPC-Boc (HY-123109), and can be used as an experimental control. (S, R, S) -AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S, R, S) -AHPC-Boc is used in PROTAC technology[1].
Product Specifications
CAS Number
[1797406-74-6]
Product Name Alternative
(S, S, S) -VH032-Boc
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-s-s-ahpc-boc.html
Purity
97.21
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)[C@H](C(C)(C)C)NC(OC(C)(C)C)=O
Molecular Formula
C27H38N4O5S
Molecular Weight
530.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10 (8) :1770‐1777.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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