EGFR-IN-112

EGFR-IN-112 (SPP10) is an EGFR kinase inhibitor which exhibits IC50s of 2.31 ± 0.3, 3.16 ± 0.8, and 4.2 ± 0.2 μM, against MCF-7, H69AR, and PC-3 cancer cells, respectively. EGFR-IN-112 also demonstrates selective cytotoxicity against cancer cells[1].

Product Specifications

CAS Number

[2758436-98-3]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-112.html

Solubility

10 mM in DMSO

Smiles

C1(C2=CC=CC=C2)=NN=C(C3=CC=CC=C3)C4=C1C(C5=CSC=C5)=NC64CCCCC6

Molecular Formula

C27H23N3S

Molecular Weight

421.56

References & Citations

[1]Harika A, et al. Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis. ACS Omega Article ASAP