A-395
A-395, a chemical probe, is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM[1].
Product Specifications
CAS Number
2089148-72-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-395.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O
Molecular Formula
C26H35FN4O2S
Molecular Weight
486.65
Precautions
H302, H315, H319, H335
References & Citations
[1]He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13 (4) :389-395.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Multiplex Assay Kit for Complement Component 3 (C3), etc. by FLIA (Flow Luminescence Immunoassay)
CAMK1D, CT (Calcium/Calmodulin-dependent Protein Kinase Type 1D, CaM kinase ID, CaM Kinase I delta, CaMKI-delta, CaM-KI delta, CaMKI delta, Camk1D, CamKI-like Protein Kinase, CKLiK, CamKI-like Protein Kinase) (FITC) discontinued
