Phosphodiesterase 10-IN-2

Phosphodiesterase 10-IN-2 (THPP-4) is an oral active phosphodiesterase 10A (PDE10A) inhibitor with the Ki of 4.5 nM. Phosphodiesterase 10-IN-2 can be used for study of schizophrenia[1].

Product Specifications

CAS Number

[1257051-56-1]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phosphodiesterase-10-in-2.html

Smiles

O=C(C1=CN(C=N1)C)N2CCC3=NC(C4=CC=C(N=C4)Cl)=NC(OC(C)C)=C3C2

Molecular Formula

C20H21ClN6O2

Molecular Weight

412.87

References & Citations

[1]Raheem IT, et al. Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2012 Sep 15;22 (18) :5903-8.