3,7-Dihydroxyflavone
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively) . 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm[1][2].
Product Specifications
CAS Number
492-00-2
Product Name Alternative
Resogalangin
UNSPSC
12352005
Hazard Statement
H315, H319
Target
17β-HSD; Aldose Reductase; Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/3-7-dihydroxyflavone.html
Purity
98.04
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13
Molecular Formula
C15H10O4
Molecular Weight
254.24
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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