3,7-Dihydroxyflavone

3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively) . 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm[1][2].

Product Specifications

CAS Number

[492-00-2]

Product Name Alternative

Resogalangin

UNSPSC

12352005

Hazard Statement

H315, H319

Target

17β-HSD; Aldose Reductase; Estrogen Receptor/ERR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/3-7-dihydroxyflavone.html

Purity

98.04

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

H315, H319

References & Citations

[1]Ma J, et al. Spectroscopic investigation on the interaction of 3,7-dihydroxyflavone with different isomers of human serum albumin. Food Chem. 2012 May 1;132 (1) :663-70.|[2]Neves MP, et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem. 2011 Jun;46 (6) :2562-74.