Lobelanidine
Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC50 of 2.8 and 8.2 μM[1].
Product Specifications
CAS Number
552-72-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
NAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lobelanidine.html
Solubility
10 mM in DMSO
Smiles
OC(CC1N(C(CCC1)CC(O)C2=CC=CC=C2)C)C3=CC=CC=C3
Molecular Formula
C22H29NO2
Molecular Weight
339.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Paz C, et al., (-) -Pentylsedinine, a new alkaloid from the leaves of Lobelia tupa with agonist activity at nicotinic acetylcholine receptor[J]. Natural Product Communications, 2015, 10 (8) : 1934578X1501000810.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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