Lobelanidine

Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC50 of 2.8 and 8.2 μM[1].

Product Specifications

CAS Number

[552-72-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lobelanidine.html

Solubility

10 mM in DMSO

Smiles

OC(CC1N(C(CCC1)CC(O)C2=CC=CC=C2)C)C3=CC=CC=C3

Molecular Formula

C22H29NO2

Molecular Weight

339.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Paz C, et al., (-) -Pentylsedinine, a new alkaloid from the leaves of Lobelia tupa with agonist activity at nicotinic acetylcholine receptor[J]. Natural Product Communications, 2015, 10 (8) : 1934578X1501000810.