Olpadronic acid

Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid also prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[63132-39-8]

Product Name Alternative

Olpadronate; OLP

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/olpadronic-acid.html

Purity

95.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O=P(O)(C(CCN(C)C)(P(O)(O)=O)O)O

Molecular Formula

C5H15NO7P2

Molecular Weight

263.12

Precautions

H315, H319, H335

References & Citations

[1]Roldán EJ, et al. Olpadronate: a new amino-bisphosphonate for the treatment of medical osteopathies. Expert Opin Investig Drugs. 1998 Sep;7 (9) :1521-38. |[2]Yang M, et al. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15;12 (8) :2602-6.