PF-00489791
PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function[1].
Product Specifications
CAS Number
853003-48-2
Product Name Alternative
PF-489791
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pf-00489791.html
Purity
99.70
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=NN(CCOCC)C2=C1N=C(N(CC)C)N=C2NC3=NC=CC(C)=C3)NS(=O)(C)=O
Molecular Formula
C20H28N8O4S
Molecular Weight
476.55
Precautions
H302, H315, H319
References & Citations
[1]Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30 (4) :283-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE5
Available Sizes
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