PF-00489791

PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function[1].

Product Specifications

CAS Number

[853003-48-2]

Product Name Alternative

PF-489791

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pf-00489791.html

Purity

99.70

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=NN(CCOCC)C2=C1N=C(N(CC)C)N=C2NC3=NC=CC(C)=C3)NS(=O)(C)=O

Molecular Formula

C20H28N8O4S

Molecular Weight

476.55

Precautions

H302, H315, H319

References & Citations

[1]Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30 (4) :283-9.