2-Aminonicotinaldehyde

2-Aminonicotinaldehyde is a key intermediate in organic synthesis. 2-Aminonicotinaldehyde can be used to synthesize 5-HT3 receptor antagonists, AKT inhibitors. 2-Aminonicotinaldehyde can be used in the research of depression and cancer (including hepatocellular carcinoma) [1][2][3].

Product Specifications

CAS Number

[7521-41-7]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Akt; Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-aminonicotinaldehyde.html

Purity

99.99

Solubility

10 mM in DMSO

Smiles

O=CC1=C(N)N=CC=C1

Molecular Formula

C6H6N2O

Molecular Weight

122.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Mahesh R, et al. Design, synthesis and evaluation of antidepressant activity of novel 2-methoxy 1, 8 naphthyridine 3-carboxamides as 5-HT3 receptor antagonists. Chem Biol Drug Des. 2014 May;83 (5) :583-91. |[2]Zhang Z, et al. Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors. J Med Chem. 2022 Feb 24;65 (4) :3249-3265.|[3]Lapierre J M, et al. Discovery of 3- (3- (4- (1-Aminocyclobutyl) phenyl) -5-phenyl-3 H-imidazo [4, 5-b] pyridin-2-yl) pyridin-2-amine (ARQ 092) : An orally bioavailable, selective, and potent allosteric AKT inhibitor[J]. Journal of medicinal chemistry, 2016, 59 (13) : 6455-6469.