DDO-7263
DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD) [1][2].
Product Specifications
CAS Number
2254004-96-9
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ddo-7263.html
Purity
99.83
Solubility
DMSO : 17.86 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NC=C(C2=NOC(C3=CC(F)=C(C=C3)F)=N2)C=C1
Molecular Formula
C14H9F2N3O
Molecular Weight
273.24
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Rat Latexin (LXN) Antibody Pair Kit (with Standard)
Rat Latexin (LXN) Antibody Pair Kit (with Standard)
Rat Latexin (LXN) Antibody Pair Kit (with Standard)
Rat Latexin (LXN) Antibody Pair Kit (with Standard)
