AKR1C3-IN-14
AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1].
Product Specifications
CAS Number
[1057882-82-2]
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c3-in-14.html
Smiles
O=C(NC1=CC=C(Br)C=C1C)CN(C)CC(C2=C(O3)C(C)=C(O)C=C2)=CC3=O
Molecular Formula
C21H21BrN2O4
Molecular Weight
445.31
References & Citations
[1]Pippione A C, et al. AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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