AKR1C3-IN-14
AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1].
Product Specifications
CAS Number
[1057882-82-2]
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c3-in-14.html
Smiles
O=C(NC1=CC=C(Br)C=C1C)CN(C)CC(C2=C(O3)C(C)=C(O)C=C2)=CC3=O
Molecular Formula
C21H21BrN2O4
Molecular Weight
445.31
References & Citations
[1]Pippione A C, et al. AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
VTCN1, ID (VTCN1, B7H4, V-set domain-containing T-cell activation inhibitor 1, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x) (MaxLight 650) discontinued
![Rabbit Monoclonal p63/TP73L Antibody (TP63/7807R) [Janelia Fluor 635]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
Rabbit Monoclonal p63/TP73L Antibody (TP63/7807R) [Janelia Fluor 635]
