Cilomilast
Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC50s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC50=74, 65, >100, and 83 μM, respectively) . Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD) [1][2][3].
Product Specifications
CAS Number
153259-65-5
Product Name Alternative
SB-207499
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Cilomilast.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1CC[C@@](C#N)(CC1)C2=CC=C(OC)C(OC3CCCC3)=C2)O
Molecular Formula
C20H25NO4
Molecular Weight
343.42
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDE4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Bovine mammalian target of rapamycin(mTOR) ELISA Kit
Bovine mammalian target of rapamycin(mTOR) ELISA Kit
Bovine mammalian target of rapamycin(mTOR) ELISA Kit
Bovine mammalian target of rapamycin(mTOR) ELISA Kit