(D) -PPA 1
(D) -PPA 1 is a hydrolysisresistant d-peptide antagonist. (D) -PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D) -PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1].
Product Specifications
CAS Number
1620813-53-7
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-ppa-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CC=CC=C5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N
Molecular Formula
C70H98N20O21
Molecular Weight
1555.65
References & Citations
[1]Chang HN, et al. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2015 Sep 28;54 (40) :11760-4.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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