ADAM9, Human (HEK293, His)

ADAM9, a metalloprotease, cleaves and releases TEK, KDR, EPHB4, CD40, VCAM1, and CDH5, playing a pivotal role in tumorigenesis and angiogenesis. It regulates cell motility through integrin interactions, mediates cell-cell and cell-matrix interactions, and may act as an alpha-secretase for APP, suggesting involvement in neurobiology and neurodegenerative disorders. ADAM9 Protein, Human (HEK293, His) is the recombinant human-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM9 Protein, Human (HEK293, His) is 669 a.a., with molecular weight of 40-45 kDa.

AARPGFQQTS HLSSYEIITP WRLTRERREA PRPYSKQVSY VIQAEGKEHI IHLERNKDLL PEDFVVYTYN KEGTLITDHP NIQNHCHYRG YVEGVHNSSI ALSDCFGLRG LLHLENASYG IEPLQNSSHF EHIIYRMDDV YKEPLKCGVS NKDIEKETAK DEEEEPPSMT QLLRRRRAVL PQTRYVELFI VVDKERYDMM GRNQTAVREE MILLANYLDS MYIMLNIRIV LVGLEIWTNG NLINIVGGAG DVLGNFVQWR EKFLITRRRH DSAQLVLKKG FGGTAGMAFV GTVCSRSHAG GINVFGQITV ETFASIVAHE LGHNLGMNHD DGRDCSCGAK SCIMNSGASG SRNFSSCSAE DFEKLTLNKG GNCLLNIPKP DEAYSAPSCG NKLVDAGEEC DCGTPKECEL DPCCEGSTCK LKSFAECAYG DCCKDCRFLP GGTLCRGKTS ECDVPEYCNG SSQFCQPDVF IQNGYPCQNN KAYCYNGMCQ YYDAQCQVIF GSKAKAAPKD CFIEVNSKGD RFGNCGFSGN EYKKCATGNA LCGKLQCENV QEIPVFGIVP AIIQTPSRGT KCWGVDFQLG SDVPDPGMVN EGTKCGAGKI CRNFQCVDAS VLNYDCDVQK KCHGHGVCNS NKNCHCENGW APPNCETKGY GGSVDSGPTY NEMNTALRD