6K465
6K465 is a pyrimidine-based Aurora A (AURKA) inhibitor. 6K465 can reduce the levels of c-MYC and N-MYC oncoproteins, demonstrating anticancer activity[1].
Product Specifications
CAS Number
[2702965-27-1]
UNSPSC
12352005
Target
Aurora Kinase; c-Myc
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6k465.html
Purity
98.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(NC2=NC(N3CCN(CC)CC3)=CC(NC4=NNC(C)=C4)=N2)CC1)C5=CC=CC(Cl)=C5F
Molecular Formula
C26H33ClFN9O
Molecular Weight
542.05
References & Citations
[1]Chang C P, et al. Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus[J]. Molecular Cancer Therapeutics, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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