C24:1-Ceramide

C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3].

Product Specifications

CAS Number

[54164-50-0]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; GSK-3

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/c24-1-ceramide.html

Purity

99.89

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O

Molecular Formula

C42H81NO3

Molecular Weight

648.10

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Gudz, T.I., et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272 (39), 24154-24158 (1997) . |[2]ugé, N., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271 (32), 19251-19255 (1996) . |[3]Gu, Q., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244 (2), 347-356 (1997) . |[4]Kong JN, et al. Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell. 2015 Dec 1;26 (24) :4451-65.