β-Amyrin acetate

β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase[1][2][3][4].

Product Specifications

CAS Number

[1616-93-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Fungal; HMG-CoA Reductase (HMGCR)

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/β-amyrin-acetate.html

Purity

99.89

Solubility

Ethanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])CC(C)(CC4)C)C)C)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(C)=O)C)([H])CC1)C

Molecular Formula

C32H52O2

Molecular Weight

468.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Nkeoma Nkasi Okoye, et al. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharm Biol. 2014 Nov;52 (11) :1478-86. |[2]Ranjani Maurya, et al. β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves. Phytomedicine. 2012 Jun 15;19 (8-9) :682-5. |[3]M.B.Gupta, et al. Biochemical study of the anti-inflammatory activity of α and β-amyrin acetate. Biochemical Pharmacology. 1971 Feb; 2 (20) : 401-405. |[4]S Johann, et al. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. Lett Appl Microbiol. 2007 Aug;45 (2) :148-53.