Human Exodus-2/CCL21 (Recombinant)

<strong>Human Exodus-2/CCL21</strong>_x000D_ <strong>Catalog number:</strong> B2010357_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human Exodus-2/CCL21 expressed in E. coli. This protein acts as a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cell and dendritic cells into lymphoid T areas._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Christopherson K 2nd, Brahmi Z, Hromas R. Regulation of naïve fetal T-cell_x000D_ migration by the chemokines Exodus-2 and Exodus-3. Immunol Lett. 1999 Aug_x000D_ 3;69(2):269-73._x000D_ _x000D_ 2: Robertson MJ, Williams BT, Christopherson K 2nd, Brahmi Z, Hromas R._x000D_ Regulation of human natural killer cell migration and proliferation by the_x000D_ exodus subfamily of CC chemokines. Cell Immunol. 2000 Jan 10;199(1):8-14._x000D_ _x000D_ 3: Nguyen T, Lagman C, Chung LK, Chen CH, Poon J, Ong V, Voth BL, Yang I._x000D_ Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas._x000D_ J Neuroimmunol. 2017 Apr 15;305:29-34._x000D_ _x000D_ 4: Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C,_x000D_ Broxmeyer HE. Isolation and characterization of Exodus-2, a novel C-C chemokine_x000D_ with a unique 37-amino acid carboxyl-terminal extension. J Immunol. 1997 Sep_x000D_ 15;159(6):2554-8._x000D_ _x000D_ 5: Christopherson KW 2nd, Hood AF, Travers JB, Ramsey H, Hromas RA. Endothelial_x000D_ induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. Blood._x000D_ 2003 Feb 1;101(3):801-6._x000D_ _x000D_ 6: Dijkstra IM, Hulshof S, van der Valk P, Boddeke HW, Biber K. Cutting edge:_x000D_ activity of human adult microglia in response to CC chemokine ligand 21. J_x000D_ Immunol. 2004 Mar 1;172(5):2744-7._x000D_ _x000D_ 7: Christopherson KW 2nd, Campbell JJ, Hromas RA. Transgenic overexpression of_x000D_ the CC chemokine CCL21 disrupts T-cell migration. Blood. 2001 Dec_x000D_ 15;98(13):3562-8._x000D_ _x000D_ 8: Christopherson KW 2nd, Campbell JJ, Travers JB, Hromas RA. Low-molecular-_x000D_ weight heparins inhibit CCL21-induced T cell adhesion and migration. J Pharmacol_x000D_ Exp Ther. 2002 Jul;302(1):290-5._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/10201891/">9: Jenh CH, Cox MA, Kaminski H, Zhang M, Byrnes H, Fine J, Lundell D, Chou CC,_x000D_ Narula SK, Zavodny PJ. Cutting edge: species specificity of the CC chemokine_x000D_ 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a_x000D_ ligand for the human or mouse CXCR3 receptors. J Immunol. 1999 Apr_x000D_ 1;162(7):3765-9.</a>_x000D_ _x000D_ <strong>Products Related to Human Exodus-2/CCL21 </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>