STAT3-IN-34
Product Specifications
UNSPSC Description
STAT3-IN-34 (Compound 15E) is an inhibitor for STAT3, and inhibits the nuclear translocation and transcriptional regulator activity of STAT3. STAT3-IN-34 inhibits the proliferation of cell HaCaT with IC50 of 0.008 μM. STAT3-IN-34 inhibits IL-17A expression and ameliorates Imiquimod (HY-B0180)-induced psoriasis in mice[1].
Target Antigen
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/stat3-in-34.html
Smiles
CN(CCOC1=CC=C(C=C1)C2=NOC3=C2C(C4=C(C3=O)C=CS4)=O)C
Molecular Weight
368.41
References & Citations
[1]Chen L, et al., Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment. J Med Chem. 2024 Aug 16.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169007/STAT3-IN-34-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169007/
Clinical Information
No Development Reported
Curated Selection
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