STAT3-IN-34

STAT3-IN-34 (Compound 15E) is an inhibitor for STAT3, and inhibits the nuclear translocation and transcriptional regulator activity of STAT3. STAT3-IN-34 inhibits the proliferation of cell HaCaT with IC50 of 0.008 μM. STAT3-IN-34 inhibits IL-17A expression and ameliorates Imiquimod (HY-B0180) -induced psoriasis in mice[1].

Product Specifications

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/stat3-in-34.html

Smiles

CN(CCOC1=CC=C(C=C1)C2=NOC3=C2C(C4=C(C3=O)C=CS4)=O)C

Molecular Formula

C19H16N2O4S

Molecular Weight

368.41

References & Citations

[1]Chen L, et al., Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment. J Med Chem. 2024 Aug 16.