7-Deaza-2',3'-dideoxyguanosine

7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].

Product Specifications

CAS Number

[111869-49-9]

Product Name Alternative

7-Deaza-ddG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/7-deaza-2-3-dideoxyguanosine.html

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N([C@@H]3O[C@H](CO)CC3)C=C2)NC(N)=N1

Molecular Formula

C11H14N4O3

Molecular Weight

250.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Nicholas A Boyle, et al. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta, gamma- (difluoromethylene) triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48 (7) :2695-700.