DdhCTP
DdhCTP is a nucleoside analog and inhibits the synthesis of DNA by specifically inhibiting the activity of DNA polymerase with the Ki values of 1.32 and 0.034 μM for DNA polymerase beta and DNA polymerase gamma[1][2].
Product Specifications
CAS Number
2279171-34-3
UNSPSC
12352005
Target
DNA/RNA Synthesis; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ddhctp.html
Smiles
NC(C=CN1[C@@H]2OC(COP(OP(OP(O)(O)=O)(O)=O)(O)=O)=C[C@H]2O)=NC1=O
Molecular Formula
C9H14N3O13P3
Molecular Weight
465.14
References & Citations
[1]Ciardullo G, et al. Viral RNA Replication Suppression of SARS-CoV-2: Atomistic Insights into Inhibition Mechanisms of RdRp Machinery by ddhCTP. J Chem Inf Model. 2024;64 (5) :1593-1604. |[2]Cherrington JM, et al. Kinetic analysis of the interaction between the diphosphate of (S) -1- (3-hydroxy-2-phosphonylmethoxypropyl) cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma. Biochem Pharmacol. 1994;48 (10) :1986-1988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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