Lactandrate
Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα) . Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].
Product Specifications
CAS Number
43000-65-3
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lactandrate.html
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
Molecular Formula
C31H44Cl2N2O3
Molecular Weight
563.60
References & Citations
[1]Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97 (1) :17-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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