HMG-1 (Acetyl Lys3) rabbit pAb
Function: Binds preferentially single-stranded DNA and unwinds double stranded DNA. similarity: Belongs to the HMGB family. similarity: Contains 2 HMG box DNA-binding domains.
Product Specifications
Background
Function:Binds preferentially single-stranded DNA and unwinds double stranded DNA., similarity:Belongs to the HMGB family., similarity:Contains 2 HMG box DNA-binding domains.
UniProt
P09429
Swiss Prot
P09429
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human HMG-1 (Acetyl Lys3)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
about 30kd
Storage Conditions
-20°C/1 year
Observed Molecular Weight
About 30kd
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460) . Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940) . Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity) . Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284) . Also released from apoptotic cells (PubMed:16855214, PubMed:18631454) . Active secretion from a variety of immune a
Other Product Names
High mobility group protein B1 (High mobility group protein 1; HMG-1)
Gene ID (Human)
3146
Available Sizes
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