4'-Hydroxy diclofenac (Standard)

4'-Hydroxy diclofenac (Standard) is the analytical standard of 4'-Hydroxy diclofenac. This product is intended for research and analytical applications. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9) . 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

Product Specifications

CAS Number

[64118-84-9]

UNSPSC

12352005

Target

Drug Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxy-diclofenac-standard.html

Smiles

O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl

Molecular Formula

C14H11Cl2NO3

Molecular Weight

312.15

References & Citations

[1]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56 (1) :65-8.|[2]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43 (3) :309-16.