P-1075
P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
Product Specifications
CAS Number
60559-98-0
UNSPSC
12352005
Hazard Statement
H300
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/p-1075.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CCC(N/C(NC#N)=N/C1=CC=CN=C1)(C)C
Molecular Formula
C12H17N5
Molecular Weight
231.30
Precautions
H300
References & Citations
[1]Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17 (19) :5529-35.|[2]Oldenburg O, et al. P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35 (9) :1035-42.|[3]Gross ER, et al. GSK3beta inhibition and K (ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. Basic Res Cardiol. 2007 Jul;102 (4) :341-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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