4″-C18 EGCG
4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC50 values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM[1].
Product Specifications
UNSPSC
12352005
Target
Amylases; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-c18-egcg.html
Smiles
OC(C(O)=C1)=C(O)C=C1[C@@H](O2)[C@H](OC(C3=CC(O)=C(OCCCCCCCCCCCCCCCCCC)C(O)=C3)=O)CC4=C2C=C(O)C=C4O
Molecular Formula
C40H54O11
Molecular Weight
710.85
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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