DBCO-acid

DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545) ), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2][3][4].

Product Specifications

CAS Number

[1353016-70-2]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

ADC Related

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-acid.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3

Molecular Formula

C19H15NO3

Molecular Weight

305.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25 (2) :351-61.|[2]Klein PM, et al. Click-Shielded and Targeted Lipopolyplexes. Methods Mol Biol. 2019;2036:141-164.|[3]Wang M, et al. Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions. Bioconjug Chem. 2023 Aug 16;34 (8) :1498-1507. |[4]Klein PM, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018 Sep;178:630-642.