PI3K-IN-18

PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1].

Product Specifications

CAS Number

[371943-05-4]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-in-18.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming)

Smiles

OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)SC=C3)=CC=C1

Molecular Formula

C16H15N3O2S

Molecular Weight

313.37

References & Citations

[1]Verheijen, Jeroen C et al. “Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.” Bioorganic & medicinal chemistry letters vol. 20,1 (2010) : 375-9.