β-Chlornaltrexamine (dihydrochloride)
β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception[1].
Product Specifications
CAS Number
67025-98-3
Product Name Alternative
β-CNA (dihydrochloride)
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-chlornaltrexamine-dihydrochloride.html
Smiles
O[C@]1([C@H]2C3)[C@@]4(CCN2CC5CC5)C6=C3C=CC(O)=C6O[C@@]4([H])[C@H](N(CCCl)CCCl)CC1.[H]Cl.[H]Cl
Molecular Formula
C24H34Cl4N2O3
Molecular Weight
540.35
References & Citations
[1]Reichard K L, et al. Regulation of kappa opioid receptor inactivation depends on sex and cellular site of antagonist action[J]. Molecular Pharmacology, 2020, 98 (5) : 548-558.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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