TYA-018

TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation[1].

Product Specifications

CAS Number

2653254-31-8

UNSPSC

12352005

Target

HDAC; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tya-018.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(N(CC1=NC=C(C2=NN=C(C(F)F)O2)S1)C3=CC(Cl)=CC=C3)(CC)=O

Molecular Formula

C15H13ClF2N4O3S2

Molecular Weight

434.87

References & Citations

[1]Yang J, et al. Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy. Sci Transl Med. 2022 Jul 6;14 (652) :eabl5654.