AChE-IN-62
Product Specifications
UNSPSC Description
AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1-42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1].
Target Antigen
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-62.html
Solubility
10 mM in DMSO
Smiles
CS(C1=CC=C2C(SC(NC(CN3CCN(C4=CC=CC=N4)CC3)=O)=N2)=C1)(=O)=O
Molecular Weight
431.53
References & Citations
[1]Mishra CB, et al. Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation. Biomed Pharmacother. Published online April 1, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161466/AChE-IN-62-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161466/
Clinical Information
No Development Reported
Curated Selection
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