Human CCR7 Full Length Protein, His, Flag Tag (Detergent)
The monoclonal antibody mAb-729 reacts with the human CC chemokine receptor, CCR7. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the C-terminus, followed by a Flag tag. The protein has a calculated MW of 58.9 kDa.
Accession Number
P32248
Expression Region
Gln 25 - Pro 378
Host
HEK293
Target
CCR7
Conjugation
Unconjugated
Tag
C-10xHis & C-Flag
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
85%
Bioactivity
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5
Additives
Glycerol
Molecular Weight
58.9 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
HEK293
Species
Human
Protein ID
P32248
Preservative
Glycerol
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